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…showed last 75 words of 1261 total…through mechanisms not yet identified, the ECM is altered. This, in turn, alters the signals sent from the ECM into the cell's nucleus, triggering the onset of malignancy. Scientists are in the process of studying a line of pre-malignant cells to determine whether or not there are integrin alterations (such as changes in the ratios of one or more forms of integrins to the others) that might foreshadow the structural changes that lead to cancer.