Renal Cell Carcinoma: Genetic Causes RESEARCH QUESTION BEING ANSWERED: :: How does the Von Hippel-Lindau Syndrome cause Renal Cell Carcinoma? In the course of researching information about Renal Cell Carcinoma, a cancer of the renal cells located in the kidney, the impact of Von Hippel-Lindau Syndrome and other genetic defects resulting in the formation of Renal Carcinoma was quite interesting. A great risk factor in the diagnosis of Renal Cell Cancer and the initial tumour formation …showed first 75 words of 749 total…

…showed last 75 words of 749 total…Type II disorders form Renal Carcinomas some time in their lifetime, compared to the 20-30% with Type I Renal Carcinoma. These numbers can also be attributed to external risk factors, such as Asbestos, other hazardous substances, Smoking, and other external factors. However, it is apparent that the degradation of the VHL gene can increase risk of developing Renal Cell Carcinoma dramatically by promoting the growth of excessive blood vessels, which then initiate the tumour-forming process.